SML1890

MK204

≥98% (HPLC)

• 동의어(들): 2-[5-Chloro-2-[[[(2,3,4,5,6-pentabromophenyl)methyl]amino]carbonyl]phenoxy]-acetic acid
• 실험식(Hill 표기법): C₁₆H₉Br₅ClNO₄
• CAS Number: 1959605-73-2
• Molecular Weight: 714.22
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 3 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: O=C(C1=C(OCC(O)=O)C=C(C=C1)Cl)NCC(C(Br)=C(C(Br)=C2Br)Br)=C2Br
• InChI: 1S/C16H9Br5ClNO4/c17-11-8(12(18)14(20)15(21)13(11)19)4-23-16(26)7-2-1-6(22)3-9(7)27-5-10(24)25/h1-3H,4-5H2,(H,23,26)(H,24,25)
• InChI key: QYSFXUVFRUYJCZ-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10).

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particular, hepatocellular carcinoma, and may be involved with drug resistance. MK204 appears to target a distinct AKR1B10 inner specificity pocket not present in the closely related aldose reductase. MK204 had an IC₅₀ value of 80 nM compared to an IC₅₀ value of 21.7 μM for aldose reductase.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable