추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to light brown
solubility
DMSO: 5 mg/mL, clear (warmed)
저장 온도
2-8°C
SMILES string
OC1=C2C(C(OC2)=O)=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C51
InChI
1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3
InChI key
VMEJANRODATDOF-UHFFFAOYSA-N
일반 설명
Diphyllin, a major glycoside compound, is a plant-derived lignan. It is present in Cleistanthus collinus.
애플리케이션
Diphyllin has been used to study its antibacterial and antibiofilm activities against fish pathogens.
생화학적/생리학적 작용
Diphyllin has shown potential to be used in a novel treatment for bone problems characterized by excessive resorption.
Diphyllin is a natural arylnaphthalene that exhibits potent anticancer and antiviral activities.
Diphyllin is a natural arylnaphthalene that exhibits potent anticancer and antiviral activities. It is a potent inhibitor of vacuolar H(+)-ATPase (V-ATPase) that inhibits lysosomal acidification in osteoclasts.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Mette G Sørensen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 22(10), 1640-1648 (2007-06-20)
Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds
Zhitao Zhang et al.
European journal of medicinal chemistry, 82, 466-471 (2014-06-16)
The concise syntheses of two natural diphyllin glycosides Cleistanthin-A (CA), Cleistanthoside-A (CleA) and its derivative, Cleistanthoside-A tetraacetate (CleT), have been achieved. They were evaluated for their in vitro anti-proliferative activities against MCF-7, HeLa, HepG2, HCT-116, U251 cancer cell lines by
Yapeng Lu et al.
European journal of pharmacology, 771, 130-138 (2015-12-23)
The vacuolar H(+)-ATPase (V-ATPase) has recently been proposed as a key target for new strategies in cancer treatment. Our previous work has proved that diphyllin glycoside is a novel inhibitor of V-ATPase. Here the cytotoxic effects of ZT-25, the most
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