SML1689

Eupatilin

from (Isolated from Artemisia sp.), ≥98% (HPLC), powder, lipophilic flavonoid

• 동의어(들): 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one, 5,7-Dihydroxy-3′,4′,6-trimethoxyflavone, NSC 122413
• 실험식(Hill 표기법): C₁₈H₁₆O₇
• CAS Number: 22368-21-4
• Molecular Weight: 344.32
• MDL number: MFCD13194819
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826018
• NACRES: NA.77

속성

• 제품명: Eupatilin, ≥98% (HPLC)
• 생물학적 소스: (Isolated from Artemisia sp.)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated; protect from light
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C31
• InChI: 1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3
• InChI key: DRRWBCNQOKKKOL-UHFFFAOYSA-N

설명

애플리케이션

Eupatilin has been used to investigate its inhibitory effects on intracranial hemorrhage (ICH)-induced inflammation and its anti-inflammatory mechanisms in mouse BV2 cells, in vitro. It has also been used as a standard for its quantitative estimation in Artemisia extracts by microcolumn high performance liquid chromatography with diode array (HPLC-DAD) assay.

생화학적/생리학적 작용

Eupatilin is a flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties.

Eupatilin is an important constituent in the leaves of Artemisia argyi and also an active component of DA-9601. It exhibits anti-apoptotic effects. Eupatilin provides protection against tumor necrosis factor α (TNF-α)-mediated inflammation in human umbilical vein endothelial cells. It is used in the treatment of gastritis and peptic ulcers. Eupatilin safeguards gastric epithelial cells from oxidative damage and smooth muscle cells from indomethacin-induced cell damage. Eupatilin lowers bile acid-stimulated hepatocyte apoptosis.

Flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable