SML1607

Lesinurad

≥98% (HPLC)

• 동의어(들): 2-[[5-Bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid, RDEA 594
• 실험식(Hill 표기법): C₁₇H₁₄BrN₃O₂S
• CAS Number: 878672-00-5
• Molecular Weight: 404.28
• MDL number: MFCD22572730
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825493
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 25 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: BrC1=NN=C(SCC(O)=O)N1C2=C3C(C=CC=C3)=C(C4CC4)C=C2
• InChI: 1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
• InChI key: FGQFOYHRJSUHMR-UHFFFAOYSA-N
• 유전자 정보: human ... SLC22A12(116085)

설명

생화학적/생리학적 작용

Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. Lesinurad thus reduces serum uric acid levels. Lesinurad has been approved for use in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout.

Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable