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Merck
모든 사진(1)

주요 문서

SML1538

Sigma-Aldrich

NMDI14

≥97% (HPLC)

동의어(들):

4,5-Dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-3-thiophenecarboxylic acid ethyl ester, Ethyl 2-{[(6,7–dimethyl–3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C21H25N3O4S
CAS Number:
307519-88-6
Molecular Weight:
415.51
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥97% (HPLC)

양식

powder

색상

white to beige

solubility

DMSO: 0.2 mg/mL, clear (warmed)

저장 온도

2-8°C

SMILES string

[s]1c(c(c(c1C)C)C(=O)OCC)NC(=O)CC2Nc3c(cc(c(c3)C)C)NC2=O

InChI key

QRLPSNLBUMVXBL-UHFFFAOYSA-N

애플리케이션

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:
  • to study its effects on differentiating cardiomyocytes
  • to study its effects on zebrafish pdzk1 gene-knockout embryos
  • to analyze its effects on the apoptosis of colorectal cancer cells

생화학적/생리학적 작용

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.
Potent nonsense-mediated RNA decay (NMD) inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
036M4625V

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문서 라이브러리 방문

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Nature communications, 12(1), 89-89 (2021-01-06)
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Nature communications, 12(1), 3849-3849 (2021-06-24)
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