콘텐츠로 건너뛰기
Merck
모든 사진(1)

Key Documents

SML1538

Sigma-Aldrich

NMDI14

≥97% (HPLC)

동의어(들):

4,5-Dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-3-thiophenecarboxylic acid ethyl ester, Ethyl 2-{[(6,7–dimethyl–3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate

로그인조직 및 계약 가격 보기
모든 사진(1)

About This Item

실험식(Hill 표기법):
C21H25N3O4S
CAS Number:
307519-88-6
Molecular Weight:
415.51
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥97% (HPLC)

형태

powder

색상

white to beige

solubility

DMSO: 0.2 mg/mL, clear (warmed)

저장 온도

2-8°C

애플리케이션

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:
  • to study its effects on differentiating cardiomyocytes
  • to study its effects on zebrafish pdzk1 gene-knockout embryos
  • to analyze its effects on the apoptosis of colorectal cancer cells

생화학적/생리학적 작용

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Xinyun Chen et al.
Nature communications, 12(1), 89-89 (2021-01-06)
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki is found highly expressed in developing and adult hearts. By employing the human
Greg H P Ngo et al.
Nature communications, 12(1), 3849-3849 (2021-06-24)
DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature of these structures

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.