SML1467

ASP7663

≥98% (HPLC)

• 동의어(들): (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid, (E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid
• 실험식(Hill 표기법): C₁₄H₁₄FNO₃
• CAS Number: 1190217-35-6
• Molecular Weight: 263.26
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825901
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: light orange to dark orange
• solubility: DMSO: 25 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: CC(C)CN(C1=C(F)C=CC=C1/C2=C\C(O)=O)C2=O
• InChI: 1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+
• InChI key: RCVZUIGCNAAMIC-UXBLZVDNSA-N

설명

생화학적/생리학적 작용

ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1), known to play a role for chemical sensing in the pain pathway. ASP7663 activated human, rat, and mouse TRPA1 receptors with EC₅₀ values of 510, 540, and 500 nM, respectively, and little or no affinity at more than 60 other related receptors, channels and enzymes. ASP7663 enhanced colonic motility and exerted analgesic effects against abdominal pain in mouse models.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable