SML1285
Febuxostat
98.5-102.0% (dry basis), powder, xanthine oxidase inhibitor
동의어(들):
2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid, Adenuric, Atenuri, Uloric
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C16H16N2O3S
CAS Number:
Molecular Weight:
316.37
MDL number:
UNSPSC 코드:
51111800
PubChem Substance ID:
NACRES:
NA.77
추천 제품
product name
Febuxostat, 98.5-102.0%
Quality Level
분석
98.5-102.0%
형태
powder
저장 온도
2-8°C
SMILES string
CC(C)COC1=C(C#N)C=C(C2=NC(C)=C(C(O)=O)S2)C=C1
InChI
1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)
InChI key
BQSJTQLCZDPROO-UHFFFAOYSA-N
일반 설명
Febuxostat is a potent, non-purine compound, which inhibits the expression of cytokines/chemokines. It has also been reported to inhibit LPS-induced TNF-α, VCAM-1, MMP9 and MCP-1 expression.
생화학적/생리학적 작용
Febuxostat is a potent non-purine xanithine oxidase inhibitor. Febuxostat is used in urate lowering therapies (ULTs) for the treatment of gout.
주의사항
Freely soluble in N,N-dimethyl formamide, Soluble in dimethyl sulfoxide, sparingly soluble in ethanol or trichloromethane, slightly soluble in methanol, practically insoluble in water
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Johji Nomura et al.
PloS one, 8(9), e75527-e75527 (2013-10-03)
Excess reactive oxygen species (ROS) formation can trigger various pathological conditions such as inflammation, in which xanthine oxidase (XO) is one major enzymatic source of ROS. Although XO has been reported to play essential roles in inflammatory conditions, the molecular
Yoshiro Tanaka et al.
Free radical biology & medicine, 162, 298-308 (2021-01-21)
Accumulating evidence suggests that high serum uric acid (UA) is associated with left ventricular (LV) dysfunction. Although xanthine oxidase (XO) activation is a critical regulatory mechanism of the terminal step in ATP and purine degradation, the pathophysiological role of cardiac
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