SML1277

Geldanamycin-FITC

≥98% (HPLC), from Streptomyces hygroscopicus

• 동의어(들): Geldanamycin, fluorescein isothiocyanate labeled
• 실험식(Hill 표기법): C₅₅H₆₃N₅O₁₃S
• Molecular Weight: 1034.18
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 생물학적 소스: Streptomyces hygroscopicus
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: protect from light
• 색상: yellow to yellow-orange
• solubility: DMSO: soluble 5 mg/mL
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C

설명

일반 설명

Chemical structure: benzenoid

생화학적/생리학적 작용

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable