SML0616

nTZDpa

≥98% (HPLC)

• 동의어(들): 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
• 실험식(Hill 표기법): C₂₂H₁₅Cl₂NO₂S
• CAS Number: 118414-59-8
• Molecular Weight: 428.33
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 15 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: S(c4ccccc4)c1c2c([n](c1C(=O)O)Cc3ccc(cc3)Cl)ccc(c2)Cl
• InChI: 1S/C22H15Cl2NO2S/c23-15-8-6-14(7-9-15)13-25-19-11-10-16(24)12-18(19)21(20(25)22(26)27)28-17-4-2-1-3-5-17/h1-12H,13H2,(H,26,27)
• InChI key: VUPOTURDKDMIGQ-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

nTZDpa is a non-thiazolidinedione PPARγ partial agonist and selective PPARγ modulator (SPPARγM).

nTZDpa is a non-thiazolidinedione PPARγ partial agonist and selective PPARγ modulator (SPPARγM). nTZDpa binds to PPARγ with high affinity, but partially activates the receptor in cell-based assays. nTZDpa reduces insulin resistance and hyperglycemia in obese diabetic rodents equal to TZD full agonists, but without increasing cardiac weight and adiposity.

특징 및 장점

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable