SML0471

A22 hydrochloride

≥95% (HPLC)

• 동의어(들): MreB Perturbing Compound A22, S-(3,4-Dichlorobenzyl)isothiourea hydrochloride
• 실험식(Hill 표기법): C₈H₈Cl₂N₂S · HCl
• CAS Number: 22816-60-0
• Molecular Weight: 271.59
• MDL number: MFCD00035050
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825427
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 2 mg/mL (clear solution, warmed)
• 저장 온도: 2-8°C
• SMILES string: Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1
• InChI: 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
• InChI key: VBJNMXMOMSWRDV-UHFFFAOYSA-N

설명

애플리케이션

A22 hydrochloride has been used to study its anti-biofilm activity, antibacterial, cyto and genotoxic activities. It is also used as a MreB polymerization inhibitor to understand the role of MreB polymers in Candidatus Thiosymbion oneisti and Candidatus T. hypermnestrae division.

생화학적/생리학적 작용

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable