SML0374

U-104

≥98% (HPLC)

• 동의어(들): 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide, NSC 213841
• 실험식(Hill 표기법): C₁₃H₁₂FN₃O₃S
• CAS Number: 178606-66-1
• Molecular Weight: 309.32
• MDL number: MFCD00159265
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825375
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: >15 mg/mL
• 저장 온도: 2-8°C
• SMILES string: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2
• InChI: 1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
• InChI key: YJQZNWPYLCNRLP-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable