추천 제품
분석
≥98% (HPLC)
Quality Level
형태
powder
저장 조건
desiccated
색상
white to tan
solubility
DMSO: ≥5 mg/mL
저장 온도
2-8°C
SMILES string
CCc1ccc(cc1)-c2nc(CSCC(=O)NCCc3ccccc3)c(C)o2
InChI
1S/C23H26N2O2S/c1-3-18-9-11-20(12-10-18)23-25-21(17(2)27-23)15-28-16-22(26)24-14-13-19-7-5-4-6-8-19/h4-12H,3,13-16H2,1-2H3,(H,24,26)
InChI key
QTDYVSIBWGVBKU-UHFFFAOYSA-N
일반 설명
iCRT3 is a small cell-permeable oxazole compound. It blocks cytokine secretion in lipopolysaccharide (LPS)-stimulated macrophages.
애플리케이션
iCRT3 has been used to inhibit the interactions between β-catenin and transcription factor (TCF).
iCRT3 has been used:
- for β- catenin inhibition in dual luciferase assay
- to inhibit β-catenin /TCF interactions and their transcriptional activity
- as wingless/tailess (wnt) antagonist, to determine Wnt/β-catenin signaling is essential for PROX1-mediated regulation of forkhead box protein C2 (FOXC2)(3)catenin inhibition in dual luciferase assay
- to inhibit β- catenin /TCF interactions and their transcriptional activity
- as wingless/tailess (wnt) antagonist, to determine Wnt/β-catenin signaling is essential for PROX1-mediated regulation of forkhead box protein C2 (FOXC2)
생화학적/생리학적 작용
The key mediator of Wnt signaling is the transcriptional co-activator b-catenin. In the cytoplasm, b-catenin is tightly bound to a complex that includes Axin and GSK-3b. Stimulation causes b-catenin stabilization, translocation to the nucleus and association with TCF4 to initiate transcription of responsive genes, referred to as Catenin Responsive Transcription (CRT). Virtually all Wnt-associated cancers are the result of misregulated CRT. Three inhibitors of CRT (iCRT) were identified in a screen that employed RNAi based knockdown of Axin, which stimulates CRT without affecting upstream mechanisms such as GSK activity, transduction by disheveled / frizzled, etc. These compounds are potent inhibitors of CRT reporter genes, as well as endogenous gene targets. The compounds also disrupt b-catenin-TCF4 interaction in a dose dependent manner, and cause G0/G1 arrest in colon tumor lines.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
UVB represses melanocyte cell migration and acts through beta-catenin
Bertrand JU, et al.
Experimental Dermatology, 26(10), 875-882 (2017)
Increasing beta-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis
Benham-Pyle BW, et al.
eLife, 5, e19799-e19799 (2016)
Archna Sharma et al.
Scientific reports, 7(1), 9235-9235 (2017-08-25)
The Wnt/β-catenin pathway has been involved in regulating inflammation in various infectious and inflammatory diseases. Sepsis is a life-threatening condition caused by dysregulated inflammatory response to infection with no effective therapy available. Recently elevated Wnt/β-catenin signaling has been detected in
Increasing beta-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis
Benham-Pyle BW, et al.
eLife, 5(, e19799-e19799 (2016)
Mitigation of sepsis-induced inflammatory responses and organ injury through targeting Wntbeta-catenin signaling
Sharma A, et al.
Scientific reports, 7(1), 9235-9235 (2017)
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