SML0077

VU591

≥98% (HPLC)

• 동의어(들): 2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole), 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole), 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole
• 실험식(Hill 표기법): C₁₆H₁₂N₆O₅
• CAS Number: 1222810-74-3
• Molecular Weight: 368.30
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825139
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to tan
• solubility: DMSO: ≥12 mg/mL
• 저장 온도: 2-8°C
• SMILES string: [O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
• InChI: 1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)
• InChI key: ZQPXNYLXYNRFNP-UHFFFAOYSA-N
• 유전자 정보: human ... KCNJ1(3758)

설명

애플리케이션

VU591 may be used in cell signaling studies.

생화학적/생리학적 작용

ROMK (Kir 1.1) inhibitor

VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable