SML0069
NSC 33994
≥98% (HPLC)
동의어(들):
(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI), 4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}, G6
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C28H42N2O2
CAS Number:
Molecular Weight:
438.65
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
분석
≥98% (HPLC)
양식
powder
색상
white to tan
solubility
DMSO: ≥25 mg/mL
저장 온도
2-8°C
SMILES string
CCN(CC)Cc1cc(ccc1O)C(\CC)=C(/CC)c2ccc(O)c(CN(CC)CC)c2
InChI
1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+
InChI key
QFNJFVBKASKGEU-OCEACIFDSA-N
애플리케이션
NSC 33994 may be used in Jak2-mediated cell signaling studies.
생화학적/생리학적 작용
NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms.
Potent and specific Jak2 inhibitor effective against Jak2-V617F mutation
특징 및 장점
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Guido Di Dalmazi et al.
BMJ open diabetes research & care, 8(2) (2020-10-30)
The COVID-19 pandemic forced the Italian government to issue extremely restrictive measures on daily activities since 11 March 2020 ('lockdown'), which may have influenced the metabolic control of type 1 diabetes mellitus (T1D). The aims of the study were to
Juliet Chepngeno et al.
Veterinary research, 50(1), 84-84 (2019-10-24)
Rotavirus C (RVC) has been detected increasingly in humans and swine in different countries, including the US. It is associated with significant economic losses due to diarrheal disease in nursing piglets. In this study we aimed: (1) to determine the
Elena Eremeeva et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(40), 9560-9576 (2017-05-18)
The ability of various nucleoside triphosphate analogues of deoxyguanosine and deoxycytidine with 7-deazadeoxyadenosine (A
Tetsushi Yoshikawa et al.
Journal of medical virology, 91(6), 1008-1013 (2019-01-29)
The main aims of the present study were to elucidate the systemic group A rotavirus (RVA) infection and to clarify the genetic changes of persistent virus in the X-linked severe combined immunodeficiency (SCID) patient. RotaTeq vaccine (RV5) genotype-specific real-time reverse
Yuehui Wang et al.
Methods (San Diego, Calif.), 173, 32-43 (2019-06-22)
Influx evidences show that red long non-coding RNAs (lncRNAs) play important roles in various critical biological processes, and they afffect the development and progression of various human diseases. Therefore, it is necessary to precisely identify the lncRNA-disease associations. The identification
문서
Sigma-Aldrich offers many products related to JAKs for your research needs.
관련 콘텐츠
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.