추천 제품
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to beige
solubility
H2O: ≥2 mg/mL (warmed)
저장 온도
2-8°C
SMILES string
C\C(CP(O)(O)=O)=C/C(N)C(O)=O
InChI
1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+
InChI key
BDYHNCZIGYIOGJ-DUXPYHPUSA-N
애플리케이션
CGP 37849 may be used in NMDA-mediated cell signaling studies.
생화학적/생리학적 작용
CGP 37849 induces phencyclidine-like behavioral syndrome in amygdala-kindled rats that includes ataxia, locomotion and stereotypies.
CGP 37849 is a potent orally active competitive NMDA antagonist and anticonvulsant.
Potent orally active competitive NMDA antagonist and anticonvulsant.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
K Wedzony et al.
Neuroscience, 153(4), 1370-1379 (2008-04-25)
The malfunction of glutamatergic neurotransmission in the neonatal or postnatal periods may be a risk factor for the appearance of neuroanatomical, neurochemical or functional changes that are characteristic of schizophrenia. Thus, the present study was undertaken to investigate whether blockade
Mélanie Langlois et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(49), 16523-16535 (2010-12-15)
Mesial temporal lobe epilepsy (MTLE) is characterized by focal seizures, associated with hippocampal sclerosis, and often resistance to antiepileptic drugs. The parafascicular nucleus (PF) of the thalamus is involved in the generation of physiological oscillatory rhythms. It receives excitatory inputs
Wojciech Zajaczkowski et al.
Polish journal of pharmacology, 55(5), 703-711 (2004-01-06)
In the present study, the interaction between a noncompetitive [(+)-MK-801] and a competitive (CGP 40116) NMDA receptor antagonists was tested in two different behavioral paradigms: locomotor activity test and prepulse inhibition of the acoustic startle reflex. Additionally, their effects on
Małgorzata Dybała et al.
Journal of neural transmission (Vienna, Austria : 1996), 115(11), 1519-1520 (2008-10-08)
The NMDA receptor antagonist, CGP 37849-induced reduction in immobility time in the forced swim test in mice was not antagonized by pre-treatment with the AMPA receptor antagonist NBQX. This is the first demonstration of the antidepressant effect of the NMDA
A Y Gemperle et al.
Neuroscience, 117(3), 681-695 (2003-03-06)
The mode of action of the antipsychotic drugs clozapine, haloperidol and iloperidone was investigated in layer V of prefrontal cortex slices using extracellular field potential, intracellular sharp-electrode as well as whole-cell voltage clamp recording techniques. Intracellular investigations on a broad
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