모든 사진(1)
About This Item
실험식(Hill 표기법):
C15H8ClF5N2O3
CAS Number:
Molecular Weight:
394.68
MDL number:
UNSPSC 코드:
51112008
NACRES:
NA.76
추천 제품
Quality Level
양식
powder
항생제 활성 스펙트럼
Gram-positive bacteria
동작 모드
protein synthesis | interferes
저장 온도
−20°C
SMILES string
FC1(Oc2c(ccc(c2)NC(=O)Nc3cc(c(cc3)Cl)C(F)(F)F)O1)F
InChI
1S/C15H8ClF5N2O3/c16-10-3-1-7(5-9(10)14(17,18)19)22-13(24)23-8-2-4-11-12(6-8)26-15(20,21)25-11/h1-6H,(H2,22,23,24)
일반 설명
PK150 is a recently discovered small antimicrobial compound. It is a potent analog of sorafenib, an anticancer drug. PK150 has structural similarity with triclocarban (TCC) and triclosan (TCS) with a N,N′-diaryl urea motif in common.
생화학적/생리학적 작용
PK150 is a potent antibiotic, which displays strong antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) at a sub-micromolar level. It elicits anti-biofilm activity and eliminates persisters. PK150 also shows oral bioavailability, and in vivo efficacy in mouse model.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Philipp Le et al.
Nature chemistry, 12(2), 145-158 (2019-12-18)
New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sorafenib as major hit that effectively kills MRSA strains. Varying the key structural
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