SAB5700429

Anti-Phospho-BCR-Y177 antibody produced in rabbit

• 동의어(들): ALL, BCR, BCR1, CML, D22S11, D22S662, PHL
• UNSPSC 코드: 12352203
• NACRES: NA.41
• 클론: polyclonal
• application: WB
• 종 반응성: mouse, human
• 기술: western blot: 1:500-1:2000

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: 137; 142
• 종 반응성: mouse, human
• 농도: 2.66 mg/ml
• 기술: western blot: 1:500-1:2000
• UniProt 수납 번호: P11274
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pTyr177)
• 유전자 정보: human ... BCR(613)

설명

일반 설명

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

면역원

A synthetic phosphorylated peptide around Y177 of human BCR (NP_004318.3).

물리적 형태

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

저장 및 안정성

Store at -20℃. Avoid freeze / thaw cycles.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable