SAB5700362

Anti-Phospho-Stat3-S727 antibody produced in rabbit

• 동의어(들): ADMIO, ADMIO1, APRF, HIES, STAT3, Stat3
• UNSPSC 코드: 12352203

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: 83; 87; 88
• 종 반응성: mouse, human, rat
• 농도: 0.51 mg/ml
• 기술: immunohistochemistry: 1:50-1:200; immunoprecipitation (IP): 1:50-1:100; western blot: 1:500-1:2000
• UniProt 수납 번호: P40763
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pSer727)
• 유전자 정보: human ... STAT3(6774)

설명

일반 설명

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

면역원

A synthetic phosphorylated peptide around S727 of human Stat3 (NP_644805.1).

물리적 형태

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

저장 및 안정성

Store at -20℃. Avoid freeze / thaw cycles.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable