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Merck
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Key Documents

SAB5500113

Sigma-Aldrich

Anti-GFAP antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP78, affinity isolated antibody

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

재조합

expressed in proprietary host

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

SP78, monoclonal

종 반응성

human (tested)

종 반응성(상동성에 의해 예측)

mouse, bovine, dog, rabbit, pig, rat

기술

immunohistochemistry: 1:100

동형

IgG

UniProt 수납 번호

배송 상태

wet ice

저장 온도

2-8°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... GFAP(2670)

일반 설명

Glial fibrillary acidic protein (GFAP) is a member of the class III intermediate filament protein family. It is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition, many types of brain tumors presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is particular expressed in auricular chondrocytes.

면역원

Synthetic peptide corresponding to C-terminus of human GFAP protein.

애플리케이션

Anti-GFAP antibody, Rabbit monoclonal has been used in immunocytochemistry and Immunohistochemistry.

생화학적/생리학적 작용

Glial fibrillary acidic protein (GFAP) maintains the structure and motility of astrocytes. Gfap mediates the interaction between neurons and glial cells. It is responsible for the integrity and function of blood-brain barrier. Myelination and brain injury induced astrogliosis is controlled by Gfap. Cytoskeleton disintegration is known to stimulate the release of Gfap. Upregulation of this gene is observed in traumatic brain injury such as intracerebral hemorrhage and thus serves as a biomarker. Mutation in the GFAP gene causes Alexander disease.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Increases of Plasma Levels of Glial Fibrillary Acidic Protein, Tau, and Amyloid β up to 90 Days after Traumatic Brain Injury.
Tanya B, et al.
Journal of Neurotrauma, 34(1), 66?73-66?73 (2017)
The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP.
Imura T, et al.
The Journal of Neuroscience, 23(7), 2824-2832 (2003)
Qiang Zhang et al.
The European journal of neuroscience, 46(9), 2507-2518 (2017-09-19)
Injury to the adult central nervous system (CNS) results in the formation of glial scar tissues. Glial scar-induced failure of regenerative axon pathfinding may limit axon regrowth beyond the lesion site and cause incorrect reinnervation and dystrophic appearance of stalled
Time-dependent activity of Na+/H+ exchanger isoform 1 and homeostasis of intracellular pH in astrocytes exposed to CoCl2 treatment.
Wang P, et al.
Molecular Medicine Reports, 13(5), 4443-4450 (2016)
HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation.
Yan F and Johnny J H
The Journal of Biological Chemistry, 291(43), 22819- 22829 (2016)

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