생물학적 소스
mouse
결합
Atto 390 conjugate
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
4F9
monoclonal
설명
target molecular weight: 57 kDa
형태
buffered aqueous solution
종 반응성
human (Tested)
포장
pkg of 100 μg
농도
1.0 mg/mL
기술
immunofluorescence: 1:100
western blot: 1:1000
동형
IgG2b
단백질 ID 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... PDIA3(2923)
면역원
Immunogen type: Recombinant protein
Immunogen Species: Human
Immunogen Region: See Notes section/Other
Immunogen Description: Human recombinant ERp57 (Grp58) protein corresponding to amino acids 25 - 505 (his-tagged)
Immunogen Species: Human
Immunogen Region: See Notes section/Other
Immunogen Description: Human recombinant ERp57 (Grp58) protein corresponding to amino acids 25 - 505 (his-tagged)
애플리케이션
Western blotting
Dilution 1:1000
Tissue/Cell Type Used: HeLa cell lysate
Immunofluorescence
Dilution 1:100
Tissue/Cell Type Used: HeLa
표적 설명
ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glycosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface . ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus .
물리적 형태
50% glycerol, 0.09% Sodium Azide
PBS pH 7.4
제조 메모
Derived from cell/tissue culture
저장 및 안정성
Protect from light; avoid repeated freeze-thaw cycles. Store at -20 °C long-term, 2-8 °C short-term.
기타 정보
Additional Product Details:
Immunogen region: Amino acids 25-505
Lot Expiration/Retest Date: Expires 1 year from purchase
Other:
Immunogen region: Amino acids 25-505
Immunogen region: Amino acids 25-505
Lot Expiration/Retest Date: Expires 1 year from purchase
Other:
Immunogen region: Amino acids 25-505
Purification method: Protein G purified
Product type: Primary antibody
Antibody structure: Whole Antibody
Protein ID: NP_005304.3
Product type: Primary antibody
Antibody structure: Whole Antibody
Protein ID: NP_005304.3
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
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