SAB5200020

Monoclonal Anti-MDC1 antibody produced in mouse

clone P2B11, 1 mg/mL, purified immunoglobulin

• 동의어(들): Anti-MDC1, P2B11, Anti-Nuclear factor with BRCT domains1, Anti-mediator of DNA damage checkpoint 1
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: P2B11, monoclonal
• 양식: buffered aqueous glycerol solution
• 분자량: antigen predicted mol wt 184 kDa
• 종 반응성: human, mouse, bovine, chimpanzee
• 농도: 1 mg/mL
• 기술: indirect immunofluorescence: suitable; western blot: suitable
• 동형: IgG1
• NCBI 수납 번호: NP_001010833.2
• UniProt 수납 번호: Q14676
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... MDC1(240087)

설명

일반 설명

Mediator of DNA damage checkpoint 1 (MDC1) is a nuclear protein that in humans is encoded by the MDC1 gene mapped to chromosome 6p21.33. The encoded protein is widely expressed in various types of tissues and organs. MDC1 is characterized with two BRCA1 C terminus (BRCT) domain, an N-terminal phosphoamino-acid-binding motif called a forkhead-associated (FHA) domain and large central proline/serine/threonine-rich repeat (PST) domain.

특이성

Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus.

면역원

GST-tagged recombinant protein corresponding to mouse MDC1 ar and around the N-termius

생화학적/생리학적 작용

Mediator of DNA damage checkpoint 1 (MDC1) plays a vital role in stimulation of the intra–S phase and G2-M phase checkpoints of the cell cycle in response to DNA damage. Polymorphism of the gene has been associated with the development of both the serum LDL-cholesterol concentration and hyper–LDL-cholesterolemia. Mammalian MDC1/ nuclear factor with BRCT domain 1 (NFBD1) interacts with phospho-H2AX (γH2AX) and plays a key role in DNA damage response by facilitating normal radioresistance and efficient accumulation of DNA-damage-response proteins on damaged chromatin.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable