SAB4702133

Monoclonal Anti-CD3, purified produced in mouse

• 동의어(들): CD3E, T3E, TCRE
• UNSPSC 코드: 12352203

속성

• 결합: unconjugated
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: SK7, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: ( Human), (Non-human primates)
• 농도: 1 mg/ml
• 기술: flow cytometry: suitable; immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• 동형: IgG1κ
• UniProt 수납 번호: P07766
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CD3E(916)

설명

일반 설명

CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.

특이성

The mouse monoclonal antibody SK7 recognizes an extracellular epitope on the CD3 antigen on mature human T cells. This antibody reacts with the epsilon chain of the CD3 complex. The monoclonal antibodies SK7 and UCHT1 recognize overlapping epitopes.

면역원

Human thymocytes

물리적 형태

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

제조 메모

Purified by protein-A affinity chromatography.

저장 및 안정성

Store at 2-8°C. Do not freeze.

기타 정보

The antibody solution should be gently mixed before use.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable