SAB4702062

Monoclonal Anti-HLA-E purified produced in mouse

• 동의어(들): HLA class I histocompatibility antigen, MHC class I antigen E, alpha chain E
• UNSPSC 코드: 12352203

속성

• 결합: unconjugated
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: MEM-E/02, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: ( Non-human primates), human
• 농도: 1 mg/ml
• 기술: immunohistochemistry: suitable; western blot: suitable
• 동형: IgG1
• UniProt 수납 번호: P13747
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... HLA-E(3133)

설명

일반 설명

HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).

특이성

The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of all human cell types.

면역원

Recombinant human HLA-E denaturated heavy chain.

물리적 형태

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

제조 메모

Purified by protein-A affinity chromatography.

저장 및 안정성

Store at 2-8°C. Do not freeze.

기타 정보

The antibody solution should be gently mixed before use.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable