SAB4702053

Monoclonal Anti-CD7 PE-Cyanine7 produced in mouse

• 동의어(들): GP40, LEU-9, TLA, TP41
• UNSPSC 코드: 12352203

속성

• 결합: PE-Cy7 conjugate
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: MEM-186, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 기술: flow cytometry: suitable
• 동형: IgG1
• UniProt 수납 번호: P09564
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CD7(924)

설명

일반 설명

CD7, also known as gp40, is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics.

특이성

The antibody MEM-186 reacts with an extracellular epitope of CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia.

면역원

Human acute myelogenous leukaemia cell line KG-1.

물리적 형태

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

제조 메모

Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-cyanine 7 (PE-Cy7) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

저장 및 안정성

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

기타 정보

The antibody solution should be gently mixed before use.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable