SAB4702032

Monoclonal Anti-CD120a purified low endotoxin produced in mouse

• 동의어(들): FPF, TBP1, TNF R1, TNFR55, TNFRSF1A, p60
• UNSPSC 코드: 12352203

속성

• 결합: unconjugated
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: H398, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 농도: 1 mg/ml
• 기술: FUNC: suitable; flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• 동형: IgG2a
• UniProt 수납 번호: P19438
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... TNFRSF1A(7132)

설명

일반 설명

CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

특이성

The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.

면역원

Recombinant full length human CD120a

물리적 형태

Phosphate buffered saline (PBS), pH 7.4

제조 메모

Purified by protein-A affinity chromatography.

저장 및 안정성

Store at 2-8°C. Do not freeze.

기타 정보

The antibody solution should be gently mixed before use.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1