SAB4702005

Monoclonal Anti-c-Myc tag Biotin produced in mouse

• 동의어(들): MRTL, MYCC, bHLH
• UNSPSC 코드: 12352203

속성

• 결합: biotin conjugate
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: 9E10, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: ( Human), (Tagged fusion proteins in all species)
• 농도: 1 mg/ml
• 기술: flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• 동형: IgG1
• UniProt 수납 번호: P01106
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... MYC(4609)

설명

일반 설명

The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells.

특이성

The antibody 9E10 can be used to detect the c-Myc tag.

면역원

Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-Myc.

물리적 형태

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

제조 메모

Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

저장 및 안정성

Store at 2-8°C. Do not freeze.

기타 정보

The antibody solution should be gently mixed before use.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable