SAB4700731

Monoclonal Anti-HLA-DR antibody produced in mouse

clone L243, purified immunoglobulin, buffered aqueous solution

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: L243, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: nonhuman primates, human, dog
• 농도: 1 mg/mL
• 기술: FUNC: suitable; flow cytometry: suitable; immunoblotting: suitable; immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• 동형: IgG2a
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... HLA-DRA(3122)

설명

일반 설명

Human leukocyte antigen (HLA)-DR is a member of HLA class II molecules. It is encoded by the gene mapped to human chromosome 6.(21} HLA class II molecules are highly expressed on B-Iymphocytes, but is also found at minimal levels on T-Iymphocytes, macrophages, thymus epithelial cells and selected cells of various body tissues. HLA-DR consists of a non-polymorphic α chain gene and up to three distinct highly polymorphic β chain genes.

The mouse monoclonal antibody L243 recognizes specifically HLA-DR molecules, both peptide-loaded and empty.

면역원

Human B lymphocytes

애플리케이션

Monoclonal Anti-HLA-DR antibody produced in mouse has been used in double immunofluorescent staining.

생화학적/생리학적 작용

Human leukocyte antigen (HLA)-DR activates a T-cell receptor by presenting antigenic peptides derived from extracellular proteins thus, stimulating an immune response against the antigen.{22] Mutation in the gene increases the risk of susceptibility to inflammatory bowel disease (IBD), Crohn′s disease and ulcerative colitis. Overexpression of monocytic (HLA)-DR has been observed in schizophrenic patients.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable