추천 제품
생물학적 소스
mouse
Quality Level
결합
biotin conjugate
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
DC-10, monoclonal
형태
buffered aqueous solution
종 반응성
human
농도
1 mg/mL
기술
flow cytometry: suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
2-8°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... KRT18(3875)
일반 설명
Keratin 18 (KRT 18) or cytokeratin 18 (CK18) encodes the type I intermediate filament chain keratin 18. The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues. In human chromosome, the gene KRT18 is localized on 12q13.13.
면역원
Human breast carcinoma cell line PMC-42
애플리케이션
The reagent is designed for Flow Cytometry. Suggested working dilution is 1:500. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
생화학적/생리학적 작용
Keratin 18 (KRT18/CK18) pairs with CK8 to form the intermediate filaments and maintain the integrity in hepatocytes. CK18 associates with histone H3 in the progression of hepatocellular carcinoma (HCC). Disorganization or altered levels of CK18 is related to plectin deficiency in HCC. K18 may be a marker for liver diseases. K18 is present in Mallory bodies and is elevated in alcoholic cirrhosis and alcoholic hepatitis. K18 expression is modulated by interleukin 6 (IL-6). K18 interacts with desmosomal protein/ E-cadherin and promotes cell adhesion. CK18 is cleaved by caspases during apoptosis and released into blood as caspase cleaved cytokeratin-18 (CCCK18).
특징 및 장점
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물리적 형태
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Cell death and prognosis of mortality in alcoholic hepatitis patients using plasma keratin-18
Woolbright BL, et al.
Gene Expression, 17(4), 301-312 (2017)
Interleukin-6 Induces keratin expression in intestinal epithelial cells potential role of Keratin-8 in interleukin-6-induced barrier function alterations
Wang L, et al.
The Journal of Biological Chemistry, 282(11), 8219-8227 (2007)
High serum levels of caspase-cleaved cytokeratin-18 are associated with malignant middle cerebral artery infarction patient mortality
Lorente L, et al.
BMC Neurology, 18(1), 32-32 (2018)
Cytokeratin 18-associated Histone 3 Modulation in Hepatocellular Carcinoma: A Mini Review
Lai YCC, et al.
Cancer, Genomics, and Proteomics, 14(4), 219-223 (2017)
TP53 mutation, epithelial-mesenchymal transition, and stem like features in breast cancer subtypes
Coradini D, et al.
BioMed Research International, 2012 (2012)
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