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Merck
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Key Documents

SAB4700662

Sigma-Aldrich

Monoclonal Anti-HLA-DR-PE antibody produced in mouse

clone MEM-12, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

결합

phycoerythrin (R-PE) conjugate

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

MEM-12, monoclonal

형태

buffered aqueous solution

종 반응성

human

기술

flow cytometry: suitable

동형

IgG1

배송 상태

wet ice

저장 온도

2-8°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... HLA-DRA(3122)

일반 설명

Human leukocyte antigen (HLA)-DR is a member of HLA class II molecules. It is encoded by the gene mapped to human chromosome 6. HLA class II molecules are highly expressed on B-Iymphocytes, but is also found at minimal levels on T-Iymphocytes, macrophages, thymus epithelial cells and selected cells of various body tissues. HLA-DR consists of a non-polymorphic α chain gene and up to three distinct highly polymorphic β chain genes.
The antibody MEM-12 recognizes common epitope on human HLA-DR which is dependent on the association of alpha and beta chains. DR is the isotype of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).

면역원

Thymocyte membrane

애플리케이션

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

생화학적/생리학적 작용

Human leukocyte antigen (HLA)-DR activates a T-cell receptor by presenting antigenic peptides derived from extracellular proteins thus, stimulating an immune response against the antigen. Mutation in the gene increases the risk of susceptibility to inflammatory bowel disease (IBD), Crohn′s disease and ulcerative colitis. Overexpression of monocytic (HLA)-DR has been observed in schizophrenic patients.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Reactive microglia in patients with senile dementia
of the Alzheimer type are positive for the
histoconlpatibility glycoprotein HLA-DR
McGeer PL
Neuroscience Letters, 79, 195-200 (1987)
HLA-DR peptide occupancy can be regulated with a wide variety of small molecules.
Blazekovic F
Human Vaccines & Immunotherapeutics, 12, 593-598 (2016)
Monocytic HLA DR antigens in schizophrenic patients.
Krause D
Neuroscience Research, 72, 87-93 (2012)
HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis.
Stokkers PC
Gut, 45, 395-401 (1999)

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