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Merck
모든 사진(1)

주요 문서

SAB4700622

Sigma-Aldrich

Monoclonal Anti-Ly6g-FITC antibody produced in rat

clone RB6-8C5, purified immunoglobulin, buffered aqueous solution

동의어(들):

Anti-Gr-1, Anti-Gr1, Anti-Ly-6G

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41
결합:
FITC conjugate
application:
FACS
클론:
RB6-8C5, monoclonal
종 반응성:
mouse
citations:
4
기술:
flow cytometry: suitable

생물학적 소스

rat

Quality Level

결합

FITC conjugate

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

RB6-8C5, monoclonal

양식

buffered aqueous solution

종 반응성

mouse

농도

1 mg/mL

기술

flow cytometry: suitable

동형

IgG2b

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

2-8°C

타겟 번역 후 변형

unmodified

유전자 정보

mouse ... Ly6g(546644)

관련 카테고리

일반 설명

Lymphocyte antigen 6 complex, locus G (Ly6G) is a 25kDa glycosylphosphatidylinositol (GPI)–anchored protein. It is encoded by the gene mapped to mouse chromosome 15. The encoded protein belongs to the Ly6/urokinase plasminogen activator receptor (uPAR) family. Ly6G is characterized with a “3 finger fold” motif stabilized by 4-5 disulfide bonds. Ly6G is expressed only in mice.
The rat monoclonal antibody RB6-8C5 detects Ly6G component of Gr-1 antigen, a commonly used surface marker of neutrophils.

면역원

Murine granulocytes

애플리케이션

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

생화학적/생리학적 작용

The protein folds of lymphocyte antigen 6 complex, locus G (Ly6G) help to form a docking site for other molecules. Ly6G functions as a marker for neutrophils. The encoded protein might be implicated in the modulation of leukocyte migration.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Ly6G ligation blocks recruitment of neutrophils via a β2-integrin?dependent mechanism
Wang JX
Blood, 120, 1489-1498 (2012)
Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo
Yipp BG and Kubes P
Blood, 121, 241-242 (2013)
Ly6 family proteins in neutrophil biology
Lee PY
Journal of Leukocyte Biology, 94, 585-594 (2013)
Yangyang Zhang et al.
Diabetes, 69(7), 1549-1561 (2020-04-30)
Diabetic keratopathy, a sight-threatening corneal disease, comprises several symptomatic conditions including delayed epithelial wound healing, recurrent erosions, and sensory nerve (SN) neuropathy. We investigated the role of neuropeptides in mediating corneal wound healing, including epithelial wound closure and SN regeneration.
Yong Woo Jung et al.
European journal of immunology, 39(8), 2281-2292 (2009-07-14)
Th2 lymphocytes deliver essential signals for induction of asthmatic airway inflammation. We previously found that airway antigen challenge induces recruitment of Gr-1(+) neutrophils prior to the recruitment of Th2 cells. We examined, therefore, whether Gr-1(+) cells contribute to the development

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