추천 제품
생물학적 소스
rat
Quality Level
결합
FITC conjugate
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
RB6-8C5, monoclonal
양식
buffered aqueous solution
종 반응성
mouse
농도
1 mg/mL
기술
flow cytometry: suitable
동형
IgG2b
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
2-8°C
타겟 번역 후 변형
unmodified
유전자 정보
mouse ... Ly6g(546644)
관련 카테고리
일반 설명
Lymphocyte antigen 6 complex, locus G (Ly6G) is a 25kDa glycosylphosphatidylinositol (GPI)–anchored protein. It is encoded by the gene mapped to mouse chromosome 15. The encoded protein belongs to the Ly6/urokinase plasminogen activator receptor (uPAR) family. Ly6G is characterized with a “3 finger fold” motif stabilized by 4-5 disulfide bonds. Ly6G is expressed only in mice.
The rat monoclonal antibody RB6-8C5 detects Ly6G component of Gr-1 antigen, a commonly used surface marker of neutrophils.
면역원
Murine granulocytes
애플리케이션
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
생화학적/생리학적 작용
The protein folds of lymphocyte antigen 6 complex, locus G (Ly6G) help to form a docking site for other molecules. Ly6G functions as a marker for neutrophils. The encoded protein might be implicated in the modulation of leukocyte migration.
특징 및 장점
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물리적 형태
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Ly6G ligation blocks recruitment of neutrophils via a β2-integrin?dependent mechanism
Blood, 120, 1489-1498 (2012)
Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo
Blood, 121, 241-242 (2013)
Ly6 family proteins in neutrophil biology
Journal of Leukocyte Biology, 94, 585-594 (2013)
Diabetes, 69(7), 1549-1561 (2020-04-30)
Diabetic keratopathy, a sight-threatening corneal disease, comprises several symptomatic conditions including delayed epithelial wound healing, recurrent erosions, and sensory nerve (SN) neuropathy. We investigated the role of neuropeptides in mediating corneal wound healing, including epithelial wound closure and SN regeneration.
European journal of immunology, 39(8), 2281-2292 (2009-07-14)
Th2 lymphocytes deliver essential signals for induction of asthmatic airway inflammation. We previously found that airway antigen challenge induces recruitment of Gr-1(+) neutrophils prior to the recruitment of Th2 cells. We examined, therefore, whether Gr-1(+) cells contribute to the development
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