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Merck
모든 사진(1)

Key Documents

SAB4700374

Sigma-Aldrich

Monoclonal Anti-CD41a antibody produced in mouse

clone HIP8, purified immunoglobulin, buffered aqueous solution

동의어(들):

Anti-ITGA2B

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

HIP8, monoclonal

형태

buffered aqueous solution

종 반응성

nonhuman primates, human

농도

1 mg/mL

기술

flow cytometry: suitable

동형

IgG1

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

2-8°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... ITGA2B(3674)

일반 설명

Cluster of differentiation 41 (CD41), also known as integrin subunit α 2b (ITGA2B) or GPIIb/IIIa (glycoprotein), is encoded by the gene mapped to human chromosome 17q21.31. It is a platelet-specific, surface membrane receptor.
The antibody HIP8 reacts with alpha (α) subunit of CD41 (heavy chain; 120 kDa). CD41 is mainly expressed on platelets and megakaryocytes. The antibody HIP8 blocks platelet aggregation and completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. HIP8 is useful in the morphological and physiological studies of platelets and megakaryocytes.

애플리케이션

The reagent is designed for Flow Cytometry analysis of human blood cells using 0.5 μg reagent / 1e6 cells in a suspension

생화학적/생리학적 작용

Cluster of differentiation 41(CD41) is significantly involved in platelet adhesion and thrombus formation at the location of vascular injury. Fibrinogen and many extracellular matrix proteins bind in a groove between the αand β-subunits of the integrin receptor. Platelet aggregation, induced by the binding of fibrinogen to the ITGA2B receptor, is involved in the pathogenesis of acute thrombosis in coronary heart disease, stroke and peripheral arterial disease. CD41, expressed in haematopoietic progenitors, is associated with erythroid activity and endothelial marker expression. Single-nucleotide polymorphisms (SNPs) in CD41 might be associated with the risk of acute coronary syndrome and atherosclerosis.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function.
Xiang Q
BioMed Research International (2016)
β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece.
Lin FY
The Journal of Biological Chemistry, 291, 4537-4546 (2016)
CD41 and CD45 expression marks the angioformative initiation of neovascularisation in human haemangioblastoma.
Ma D
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37, 3765-3774 (2016)

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