SAB4700142

Monoclonal Anti-CD80-FITC antibody produced in mouse

clone MEM-233, purified immunoglobulin, buffered aqueous solution

• 동의어(들): Anti-B7-1
• UNSPSC 코드: 12352203
• NACRES: NA.44

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: FITC conjugate
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: MEM-233, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 기술: flow cytometry: suitable
• 동형: IgG1
• NCBI 수납 번호: NM_005191.3
• UniProt 수납 번호: P33681
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CD80(941)

설명

일반 설명

Cluster of differentiation 80 (CD80), also called as lymphocyte activation antigen 7-1, is encoded by the gene mapped to human chromosome 3q13.33. The encoded protein is mainly expressed on antigen presenting cells such as, neutrophils, macrophages and dendritic cells.

The antibody MEM-233 reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.

면역원

Extracellular domain of human CD80 fused to human IgG1(Fc)

애플리케이션

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

생화학적/생리학적 작용

Cluster of differentiation 80 (CD80) interacts with its ligand, co-stimulator ligand CD28 or with cytotoxic T-lymphocyte protein 4 (CTLA-4) and facilitates the regulation of CD4⁺ and CD8⁺ T cell activity. Elevated urinary CD80 excretion leads to Fabry disease. CD80, which is expressed on surface of dendritic cells acts as a key co-stimulatory molecule and induces second signal for the proper stimulation of cancer antigen-specific naive T cells.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable