추천 제품
생물학적 소스
mouse
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
MEM-15, monoclonal
양식
buffered aqueous solution
종 반응성
human, nonhuman primates
농도
1 mg/mL
기술
flow cytometry: suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
2-8°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CD14(929)
일반 설명
CD14 (cluster of differentiation 14) is a myelomonocytic differentiation antigen, encoded by the gene mapped to human chromosome 5q23-31. It is mainly expressed by monocytes, macrophages and activated granulocytes.
면역원
A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria
애플리케이션
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 4 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
생화학적/생리학적 작용
CD14 (cluster of differentiation 14) serves as an important receptor of bacterial lipopolysaccharide (LPS). CD14 and LPs complex interacts with toll-like receptor 4 and enhances the expression of inflammatory mediators, including tumor necrosis factor (TNF)- and interleukin (IL)-1, via p38 mitogen-activated protein kinase and nuclear factor-B pathway. Mutation in the gene is associated with the development of myeloid leukemias and generalized chronic periodontitis (GCP).
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Synergistic contribution of CD14 and HLA loci
in the susceptibility to Buerger disease
Chen Z
Human Genetics, 122, 367-372 (2007)
The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors.
Goyert SM
Science, 239, 497-500 (1988)
Cytogenetic and molecular delineation of the smallest commonly
deleted region of chromosome 5 in malignant myeloid diseases
Le Beau MM
Proceedings of the National Academy of Sciences of the USA, 90, 5484-5488 (1993)
Dilshi Ishaan et al.
Genetic testing and molecular biomarkers, 21(9), 560-564 (2017-08-23)
The genetic variation in the CD14 rs2569190 promoter region contributes to the susceptibility of developing periodontitis. Since, CD14 gene polymorphism studies among various ethnic populations have produced conflicting results, the present study was designed to unearth the association between the
D P Funda et al.
Infection and immunity, 69(6), 3772-3781 (2001-05-12)
Human endothelial as well as epithelial cells were shown to respond to lipopolysaccharides (LPSs). However, the expression and release of CD14 by these so-called CD14-negative cells have not been studied in detail. We investigated three human intestinal epithelial cell lines
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