SAB4700005

Monoclonal Anti-CD95 antibody produced in mouse

clone LT95, purified immunoglobulin, buffered aqueous solution

• 동의어(들): Anti-FAS
• UNSPSC 코드: 12352203
• NACRES: NA.41
• 결합: unconjugated
• application: FACS
• 클론: LT95, monoclonal
• 종 반응성: human
• citations: 6
• 기술: flow cytometry: suitable

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: LT95, monoclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 농도: 1 mg/mL
• 기술: flow cytometry: suitable
• 동형: IgG1
• NCBI 수납 번호: NM_000043.3
• UniProt 수납 번호: P25445
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... FAS(355)

설명

일반 설명

CD95, also known as Fas (fatty acid synthase) cell surface death receptor/APO-1, is encoded by the gene mapped to human chromosome 10q23.31. The encoded protein belongs to the tumor necrosis factor receptor superfamily and is expressed on a variety of cells including activated T and B cells. CD95 contains a death domain.

The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.

면역원

HUT-78 human T cell lymphoma cell line

애플리케이션

Monoclonal Anti-CD95 antibody produced in mouse has been used as a apoptosis inducer.

생화학적/생리학적 작용

CD95/ Fas (fatty acid synthase) cell surface death receptor interacts with its natural ligand (FasL/CD95 L) and plays a vital role in regulation of T-cell homeostasis, by promoting apoptosis via activation-induced cell death (AICD). Mutation in the gene has been associated with the development of Sézary syndrome (SS) and Canale–Smith syndrome. CD95 gene loss can be used as a genetic marker of PSA recurrence after radical prostatectomy.

특징 및 장점

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물리적 형태

Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable