추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 101 kDa
종 반응성
rat, mouse, human
농도
~1 mg/mL
기술
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pTyr513)
유전자 정보
human ... DDR1(780)
일반 설명
Discoidin domain receptor I (DDR1) is a receptor tyrosine kinase (RTK)/collagen-activated tyrosine kinase, that is located on human chromosome 6p21.
면역원
The antiserum was produced against synthesized peptide derived from human DDR1 around the phosphorylation site of Tyr513.
Immunogen Range: 479-528
Immunogen Range: 479-528
생화학적/생리학적 작용
Discoidin domain receptor I (DDR1) plays important roles in several cancers. In renal cancer cells, DDR1 promotes epithelial to mesenchymal transition. It also increases invasion and metastasis of gastric cancer through epithelial-mesenchymal transition.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
DDR1 enhances invasion and metastasis of gastric cancer via epithelial-mesenchymal transition
Xie R, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(9), 12049-12059 (2016)
Receptor protein tyrosine kinase DDR is up-regulated by p53 protein
Sakuma S, et al.
Febs Letters, 398(2-3), 165-169 (1996)
Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells
Song J, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(8), 11509-11521 (2016)
Fabian Baltes et al.
International journal of molecular sciences, 21(14) (2020-07-17)
Collagen type 1 (COL1) is a ubiquitously existing extracellular matrix protein whose high density in breast tissue favors metastasis and chemoresistance. COL1-binding of MDA-MB-231 and MCF-7 breast cancer cells is mainly dependent on β1-integrins (ITGB1). Here, we elucidate the signaling
Nuno M Coelho et al.
Cells, 9(7) (2020-07-16)
DDR1 is a collagen adhesion-mechanoreceptor expressed in fibrotic lesions. DDR1 mediates non-muscle myosin IIA (NMIIA)-dependent collagen remodeling. We discovered that the myosin phosphatase Rho-interacting protein (MRIP), is enriched in DDR1-NMIIA adhesions on collagen. MRIP regulates RhoA- and myosin phosphatase-dependent myosin
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