SAB4503272

Anti-CASP-1 (Cleaved-Asp²¹⁰) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): ICE, IL-1 β, IL-1 β converting enzyme, IL-1BC, caspase-1
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 25 kDa; antigen 45 kDa
• 종 반응성: human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI 수납 번호: P29466
• UniProt 수납 번호: P29466
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: proteolytically cleaved (Asp210)
• 유전자 정보: human ... CASP1(834)

설명

일반 설명

Anti-CASP-1 (Cleaved-Asp²¹⁰) Antibody detects endogenous levels of fragment of activated CASP-1 (Cleaved-Asp²¹⁰) protein.

Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on human chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. CASP-1 is present in leukocytes, monocytes and epithelial cells.

면역원

The antiserum was produced against synthesized peptide derived from human IL-1 beta.

Immunogen Range: 161-210

생화학적/생리학적 작용

Caspase-1 can transform pro-inflammatory cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18) into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. CASP-1 helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable