SAB4503023

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): C1 esterase, C1S, Complement C1s subcomponent, Complement component 1 subcomponent s
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 47 kDa; antigen 76 kDa
• 종 반응성: human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:20000; western blot: 1:500-1:1000
• NCBI 수납 번호: P09871
• UniProt 수납 번호: P09871
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: proteolytically cleaved (Arg437)
• 유전자 정보: human ... C1S(716)

설명

일반 설명

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷ Antibody detects endogenous levels of fragment of activated C1S (heavy chain, Cleaved-Arg⁴³⁷protein.

The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.

면역원

The antiserum was produced against synthesized peptide derived from human C1S.

Immunogen Range: 388-437

생화학적/생리학적 작용

Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated lupus nephritis, with low gene expression observed in mice.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable