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Merck
모든 사진(1)

주요 문서

SAB4502987

Sigma-Aldrich

Anti-TSG6 antibody produced in rabbit

affinity isolated antibody

동의어(들):

α-induced protein 6, TSG6, tumor necrosis factor

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 31 kDa

종 반응성

human, mouse

농도

~1 mg/mL

기술

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... TSG6(7130)

일반 설명

Anti-TSG6 Antibody detects endogenous levels of total TSG6 protein.
Tumor necrosis factor (TNF)-α–stimulated gene 6 protein (TSG-6) is an inflammation-associated secreted protein. It has a molecular weight of about 35 kDa. TSG-6 possesses Link and CUB_C domains, along with a with a short amino-terminal sequence. The gene encoding this protein is localized on human chromosome 2q23.3.

면역원

The antiserum was produced against synthesized peptide derived from human TSG6.

Immunogen Range: 21-70

생화학적/생리학적 작용

Tumor necrosis factor (TNF)-α–stimulated gene 6 protein (TSG-6) has been implicated in regulation of cell-cell and cell-matrix interactions during inflammation and tumorigenesis. TSG-6 possesses anti-inflammatory properties. It is also known to reduce inflammatory reactions triggered by ischemia in the heart. Thus, it might have a potential role in treating heart disease with other cells such as skeletal myoblasts, fetal myoblasts and embryonic stem cells.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine/glycosaminoglycan interactions.
Dyer DP, et al.
The Journal of Biological Chemistry (2016)
A Novel Allelic Variant of the Human TSG-6 Gene Encoding an Amino Acid Difference in the CUB Module CHROMOSOMAL LOCALIZATION, FREQUENCY ANALYSIS, MODELING, AND EXPRESSION.
Nentwich HA, et al.
The Journal of Biological Chemistry, 277(18), 15354-15362 (2002)
A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
Lee T H, et al.
The Journal of Cell Biology, 116(2), 545-557 (1992)
Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6.
Ryang H L, et al.
Cell Stem Cell, 5(1), 54-63 (2009)
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
Choi H, et al.
Blood (2011)

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