SAB4502371

Anti-PKD1 antibody produced in rabbit

affinity isolated antibody

• 동의어(들): KPCD1, PKC-mu, PKCM, PKD, PRKCM
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen 101 kDa
• 종 반응성: mouse, human, rat
• 농도: ~1 mg/mL
• 기술: ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI 수납 번호: Q15139
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... KPCD1(5587)

설명

일반 설명

Anti-PKD1 Antibody detects endogenous levels of total PKD1 protein.

Polycystic kidney disease 1/polycystin-1 (PKD1/PC1) gene comprises of 46 exons and spans approximately 52 kb of genomic sequence. Polycystin-1 (PC1) is expressed at high levels in the brain and moderately in the kidney in adult tissue. It is present in the primary cilium of most mammalian cells. PC1 is also located at focal adhesions, desmosomes, and adherens junctions in the plasma membrane. Anti-PKD1 antibody detects endogenous levels of total PKD1 protein.

면역원

The antiserum was produced against synthesized peptide derived from human PKD1/PKC mu.

Immunogen Range: 171-220

애플리케이션

Anti-PKD1 antibody produced in rabbit has been used in western blot analysis(1:500).

생화학적/생리학적 작용

Polycystic kidney disease 1/polycystin-1 (PKD1/PC1) plays a regulatory role in cell migration and cell proliferation through mammalian targets of rapamycin (mTOR) and Janus kinase (JAK) signals. PKD1 inhibits cell migration and in some situations, acts as a tumor suppressor protein in the lung cancer cell line (A549). Before birth, polycystin-1 is the most active protein in kidney cells, and it interacts and works with polycystin-2 (PKD2). Mutations in the PKD1 gene are responsible for 85 percent of polycystic kidney diseases (PKDs).

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable