추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 59 kDa
종 반응성
human
농도
~1 mg/mL
기술
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
proteolytically cleaved (Val1432)
유전자 정보
human ... NOTCH4(4855)
일반 설명
Anti-NOTCH4 (Cleaved-Val1432) antibody detects endogenous levels of fragment of activated NOTCH4 (Cleaved-Val1432) protein.
The NOTCH4 gene is mapped to human chromosome 6p21.32.
면역원
The antiserum was produced against synthesized peptide derived from human NOTCH4.
Immunogen Range: 1401-1450
Immunogen Range: 1401-1450
생화학적/생리학적 작용
The NOTCH4 gene is associated with the process of angiogenesis and homeostasis during developmental process. NOTCH4 plays a role in Notch signaling pathway which mediates epithelial cell and stem cell homeostasis. Notch signaling pathway is induced in a number of cancer types including colon, breast, pancreatic, cervical, head and neck, renal carcinoma, prostate cancer, Large-cell and Hodgkin lymphomas.Thus, NOTCH4 is known to participate in tumorigenesis. This gene is involved in the development of central nervous system and controls neuronal maturation. Mutations in the gene might be associated with schizophrenia.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Jianwen Xiong et al.
Oncotarget, 8(8), 13157-13165 (2017-01-07)
Notch signalling is aberrantly activated in human non-small cell lung cancer (NSCLC). Nevertheless, the prognostic roles of mRNA expression of four Notch receptors in NSCLC patients remain elusive. In this report, we reported the prognostic roles of Notch receptors in
Harishankar Mk et al.
Life sciences, 156, 38-46 (2016-05-20)
Despite the development of several therapeutic strategies in the past decades, clinicians have failed to improve the survival rate of oral squamous cell carcinoma patients due to the highly metastatic nature of the disease and its high recurrence rate. However
Bao Zhang et al.
BioMed research international, 2015, 408096-408096 (2015-11-26)
NOTCH4 regulates signaling pathways associated with neuronal maturation, a process involved in the development and patterning of the central nervous system. The NOTCH4 gene has also been identified as a possible susceptibility gene for schizophrenia (SCZ). The objective of this
Xiaoxia Liu et al.
Reproduction (Cambridge, England), 152(1), 47-55 (2016-04-14)
Preeclampsia is a serious complication of pregnancy and is closely related to endothelial dysfunction, which can be repaired by endothelial progenitor cells (EPCs). The DLL4/NOTCH-EFNB2 (ephrinB2) cascade may be involved in the pathogenesis of preeclampsia by inhibiting the biological activity
Seema R Lalani et al.
BMC medical genetics, 6, 8-8 (2005-02-16)
CHARGE syndrome is a complex of birth defects including coloboma, choanal atresia, ear malformations and deafness, cardiac defects, and growth delay. We have previously hypothesized that CHARGE syndrome could be caused by unidentified genomic microdeletion, but no such deletion was
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