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Merck
모든 사진(2)

주요 문서

SAB4501599

Sigma-Aldrich

Anti-JAK2 antibody produced in rabbit

affinity isolated antibody

동의어(들):

JAK-2, JAK2, Janus kinase 2, kinase Jak2

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen 130 kDa

종 반응성

mouse, rat, human

농도

~1 mg/mL

기술

ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... JAK2(3717)

일반 설명

Anti-JAK2 antibody detects endogenous levels of total JAK2 protein.
JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the the Jak family of proteins. It is located on human chromosome 9p24.

면역원

The antiserum was produced against synthesized peptide derived from human JAK2.

Immunogen Range: 541-590

생화학적/생리학적 작용

JAK2 (janus kinase 2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells
Borriello L, et al.
Cancer Research (2017)
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2
Joos S, et al.
International Journal of Cancer. Journal International Du Cancer, 103(4), 489-495 (2003)
Jak2 is essential for signaling through a variety of cytokine receptors
Parganas E, et al.
Cell, 93(3), 385-395 (1998)
Xiaoping Pan et al.
Life sciences, 214, 124-135 (2018-11-06)
Although the anti-neoplastic effects of physcion are well documented, its specific action in hepatocellular carcinoma (HCC) is not understood. Taken together, physcion is a promising drug candidate for the treatment and prevention of HCC. Cell Counting Kit-8 (CCK-8) assay utilized
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7(2), 188-201 (2017)

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