생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 72 kDa
종 반응성
mouse, rat, human
농도
~1 mg/mL
기술
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... HSPA5(3309)
관련 카테고리
일반 설명
Glucose/regulated protein 78 (GRP78) is a stress-associated protein. It is mapped to human chromosome 9q33.3. It is also known as HSPA5 (heat shock 70kDa protein 5) and immunoglobulin heavy chain binding protein (BiP). It is present in nucleated cells like thyroid, lung, smooth muscle, liver and several cells of the immune system.
The molecular weight of GRP78 is 78kDa.
면역원
The antiserum was produced against synthesized peptide derived from human GRP78.
Immunogen Range: 605-654
Immunogen Range: 605-654
생화학적/생리학적 작용
GRP78 levels are elevated during various human cancers and tumors.
Glucose/regulated protein 78 (GRP78) participates in stress-associated diseases. It also participates in protein biogenesis (protein transport into the endoplasmic reticulum (ER), protein folding and assembly and ER associated protein degradation), signal transduction and calcium homeostasis.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders
Wang M, et al.
Antioxidants & Redox Signaling, 11(9), 2307-2316 (2009)
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions
Fernandez P M, et al.
Breast Cancer Research and Treatment, 59(1), 15-26 (2000)
Eman Radwan et al.
Journal of molecular and cellular cardiology, 143, 15-25 (2020-04-21)
Metabolic (Met) syndrome is characterized by hypertension, insulin resistance and dyslipidaemia with high risk of cardiovascular disease. Endoplasmic reticulum (ER) stress is a key contributor in the pathogenesis of Met syndrome. The current study investigates the effect of Tauroursodeoxycholate (TUDCA)
Lin Ma et al.
Biochemical and biophysical research communications, 533(4), 1449-1456 (2020-11-11)
DEAD-Box Helicase 5(DDX5), also known as P68, is one of the founding members of the DEAD-Box helicase superfamily and it plays a key role in RNA metabolism. Several studies have reported that DDX5 is involved in many types of tumors
HSPA5 (heat shock 70kDa protein 5 (glucoseregulated protein, 78kDa)).
Zimmermann R and Dudek J
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2010)
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