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Merck
모든 사진(2)

주요 문서

SAB4500896

Sigma-Aldrich

Anti-COPZ1 antibody produced in rabbit

affinity isolated antibody

동의어(들):

ζ1-COP, CGI-120, COPZ, coatomer protein complex, subunit ζ 1

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen 20 kDa

종 반응성

human, mouse

농도

~1 mg/mL

기술

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... COPZ1(22818)

일반 설명

Anti-COPZ1 Antibody detects endogenous levels of total COPZ1 protein.

COPZ1 (coatomer protein complex ζ1) codes for a subunit of coatomer protein complex 1 (COPI). It is a secretory vesicle coat protein. It is located on human chromosome 12q13.

면역원

The antiserum was produced against synthesized peptide derived from human COPZ1.

Immunogen Range: 11-60

애플리케이션

Anti-COPZ1, N-Terminal antibody has been used in immunohistochemistry , immunofluorescence and western blotting.

생화학적/생리학적 작용

COPZ1 (coatomer protein complex ζ1) participates in intracellular traffic and autophagy, and endosome maturation. Suppression of COPZ1 promotes apoptosis in proliferating and nondividing tumor cells.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Maria Chiara Anania et al.
Cancer letters, 410, 201-211 (2017-09-28)
Thyroid carcinoma is generally associated with good prognosis, but no effective treatments are currently available for aggressive forms not cured by standard therapy. To find novel therapeutic targets for this tumor type, we had previously performed a siRNA-based functional screening
Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway
Narkis G, et al.
American Journal of Human Genetics, 81, 589-595 (2007)
Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ? 2 renders tumor cells dependent on its paralogous gene COPZ1
Shtutman M, et al.
Proceedings of the National Academy of Sciences of the USA, 108, 12449-12454 (2011)
Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells
Anania MC, et al.
Cancer Letters, 410, 201-211 (2017)
Eileen Sun et al.
Journal of virology, 87(5), 2673-2685 (2012-12-21)
As an obligate pathogen, influenza virus requires host cell factors and compartments to mediate productive infection and to produce infectious progeny virus. Recently, several small interfering RNA (siRNA) knockdown screens revealed influenza virus host dependency proteins, all of which identified

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