추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 46 kDa
종 반응성
human
농도
~1 mg/mL
기술
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
proteolytically cleaved (Ser42)
유전자 정보
human ... F2R(2149)
일반 설명
Anti-PAR1 (Cleaved-Ser42) Antibody detects endogenous levels of fragment of activated PAR1 (Cleaved-Ser42) protein.
Protease-activated receptor-1 (PAR1), also known as coagulation factor II thrombin receptor (F2R), is encoded by the gene mapped to human chromosome 5q13.3. The encoded protein is a cell surface seven-transmembrane G protein coupled receptor.
Protease-activated receptor-1 (PAR1), also known as coagulation factor II thrombin receptor (F2R), is encoded by the gene mapped to human chromosome 5q13.3. The encoded protein is a cell surface seven-transmembrane G protein coupled receptor.
면역원
The antiserum was produced against synthesized peptide derived from human PAR1.
Immunogen Range: 23-72
Immunogen Range: 23-72
애플리케이션
Anti-PAR1 (Cleaved-Ser42), N-Terminal antibody produced in rabbit has been used in Western blotting.
생화학적/생리학적 작용
Protease-activated receptor-1 (PAR1) facilitates angiogenesis and influences the process of tumor growth and disease progression. In addition, it also plays a vital role in inflammation and thrombosis. Mutation in the gene is associated with an increased risk of metastasis and poorer prognosis of renal cell carcinoma. Elevated expression of the gene has been observed in various types of cancers, such as ovarian, breast, lung, prostate cancer and melanoma.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer.
Lin C, et al.
BMC Cancer, 17(1), 113-113 (2017)
Barry S Shea et al.
JCI insight, 2(9) (2017-05-05)
Fibrotic lung disease, most notably idiopathic pulmonary fibrosis (IPF), is thought to result from aberrant wound-healing responses to repetitive lung injury. Increased vascular permeability is a cardinal response to tissue injury, but whether it is mechanistically linked to lung fibrosis
Zhuang-Zhuang Tang et al.
Naunyn-Schmiedeberg's archives of pharmacology (2021-11-19)
Upregulation of thrombin receptor protease-activated receptor 1 (PAR-1) is verified to contribute to chronic kidney diseases, including diabetic nephropathy; however, the mechanisms are still unclear. In this study, we investigated the effect of PAR-1 on high glucose-induced proliferation of human
Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis.
Shea B S, et al.
JCI insight, 2(9) (2017)
The protease activated receptor 1 gene variation IVSn?14 A> T is associated with distant metastasis and cancer specific survival in renal cell carcinoma.
de Martino M, et al.
The Journal of Urology, 190(4), 1392-1397 (2013)
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