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Merck
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Key Documents

SAB4500753

Sigma-Aldrich

Anti-APOBEC3A antibody produced in rabbit

affinity isolated antibody

동의어(들):

Phorbolin-1

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 23 kDa

종 반응성

human

농도

~1 mg/mL

기술

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

관련 카테고리

일반 설명

APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) belongs to the AID/APOBEC family of enzymes. It is located on human chromosome 22q13.1.
Anti-APOBEC3A antibody detects endogenous levels of total APOBEC3A protein.

면역원

The antiserum was produced against synthesized peptide derived from human APOBEC3A.

Immunogen Range: 27-76

애플리케이션

Anti-APOBEC3A antibody has been used in western blotting.

생화학적/생리학적 작용

APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) deaminates methylated cytosine bases in DNA. It is considered as a viral DNA mutator and performs broad antiviral activity.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A
Aynaud MM, et al.
The Journal of Biological Chemistry (2012)
Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage
Suspene R, et al.
Nucleic Acids Research, 45(6), 3231-3241 (2017)
Heat Increases the Editing Efficiency of Human Papillomavirus E2 Gene by Inducing Upregulation of APOBEC3A and 3G
Yang Y, et al.
The Journal of Investigative Dermatology, 137(4), 810-818 (2017)
APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA
Schutsky EK, et al.
Nucleic Acids Research, 45(13), 7655-7665 (2017)
Jan-Hendrik Bockmann et al.
The Journal of infectious diseases, 220(4), 567-577 (2019-03-30)
Type III interferons (IFNs) (λ1-3) activate similar signaling cascades as type I IFNs (α and β) via different receptors. Since IFN-α and lymphotoxin-β activate cytosine deamination and subsequent purging of nuclear hepatitis B virus (HBV) DNA, we investigated whether IFN-β

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