생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 91 kDa
종 반응성
mouse, human
농도
~1 mg/mL
기술
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MAP3K1(4214)
일반 설명
Anti-MEKKK 1 Antibody detects endogenous levels of total MEKKK 1 protein. The MEKKK 1 (mitogen-activated protein kinase kinase kinase 1) gene is mapped to human chromosome 5q11.2 and codes for serine/threonine kinase protein containing a plant homeodomain.
면역원
The antiserum was produced against synthesized peptide derived from human MEKKK 1.
Immunogen Range: 371-420
Immunogen Range: 371-420
생화학적/생리학적 작용
MEKKK 1 (mitogen-activated protein kinase kinase kinase 1) controls different processes associated with inflammation and apoptosis. In response to upstream signals, the members of the MAPK (mitogen-activated protein kinase) family gets activated upon phosphorylation. MEKKK 1 possesses E3 ubiquitin ligase activity in relation to c-Jun protein stability and regulates the JNK (c-Jun NH2-terminal kinases) pathway. MEKKK 1 gene regulation is associated with acute respiratory distress syndrome.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome.
American Journal of Respiratory Cell and Molecular Biology, 58(1), 117-125 (2018)
Nuclear localization signal and p53 binding site in MAP/ERK kinase kinase 1 (MEKK1).
Journal of Cellular Biochemistry, 116(12), 2903-2914 (2015)
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11. 2 and 14q24. 1 (RAD51L1).
Nature Genetics, 41(5), 579-579 (2009)
CSN6 positively regulates c-Jun in a MEKK1-dependent manner.
Cell Cycle, 14(19), 3079-3087 (2015)
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