생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
17 kDa
종 반응성
rat, mouse, human
농도
1.0 mg/mL
기술
western blot: 1:500-1:1000 (Cell Lysate)
동형
IgG
수납 번호(accession number)
NP_005175.2
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pThr79)
유전자 정보
human ... CALM3(808)
일반 설명
Calmodulin 3 (CALM3) encodes calmodulin (CaM) protein 3 which is expressed five folds more than CALM1 and CALM2. CALM3 promoter has high GC content and no TATA box like that of housekeeping gene. CALM3 contains several pro-alpha1 (AP1) and pro-alpha2 (AP2) consensus sites and several CAAT regions. CALM3 also has clusters of specificity protein 1 (SP1) transcription factor. In human chromosome, the gene is localized on 19q13.32.
특이성
The antibody detects endogenous level of Calmodulin only when phosphorylated at threonine 79/serine 81.
면역원
Peptide sequence around phosphorylation site of threonine79/serine81(K-D-T(p)-D-S(p)-E-E) derived from Human Calmodulin .
생화학적/생리학적 작용
Calmodulin (CaM) encoded by Calmodulin 3 (CALM3) senses Ca2+ and binds to free signal-transducing protein that regulates Cav1.2 L-type calcium channel and deactivates Cav1.2 when CaM binds to free Ca2+. A sporadic mutation in CALM3 might be the cause for long QT syndrome, a disorder of ventricular myocardial repolarization, characterized by prolonged heart rate. CALM3 expression is higher in teratoma cells. CALM3 is a potential biomarker to dysregulate the melanoma cancer genes. Polymorphism in CALM3 is a potential modifier gene for familial hypertrophic cardiomyopathy.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALMS
Toutenhoofd SL, et al.
Cell Calcium, 23(5), 323-338 (1998)
Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer
Goto Y, et al.
Febs Letters, 588(10), 1973-1982 (2014)
A new polymorphism in human calmodulin III gene promoter is a potential modifier gene for familial hypertrophic cardiomyopathy
Friedrich FW, et al.
European Heart Journal, 30(13), 1648-1655 (2009)
CALM3 mutation associated with long QT syndrome
Reed GJ, et al.
Heart Rhythm : the Official Journal of the Heart Rhythm Society, 12(2), 419-422 (2015)
Identification of melanoma biomarkers based on network modules by integrating the human signalling network with microarrays
Huang C, et al.
Journal of Cancer Research and Therapeutics, 10(7), 114-124 (2014)
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