SAB4300606
Anti-LYVE1 antibody produced in rabbit
affinity isolated antibody
동의어(들):
Anti-CRSBP-1 antibody produced in rabbit, Anti-HAR antibody produced in rabbit, Anti-LYVE-1 antibody produced in rabbit, Anti-XLKD1 antibody produced in rabbit, Anti-lymphatic vessel endothelial hyaluronan receptor 1 antibody produced in rabbit
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모든 사진(1)
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
~40 kDa
종 반응성
mouse, human, rat
농도
1 mg/mL
기술
western blot: 1:500-1:1000
동형
IgG
면역원 서열
(K-N-Q-Q-K)
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... LYVE1(10894)
일반 설명
LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1) is a type I integral membrane polypeptide. It is present on lymph vessel endothelial cells of both normal and neoplastic tissues. LYVE consists of a single N-terminal HA binding domain. It is mapped to human chromosome 11p15.
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as CRSBP, is encoded by the gene localized on human chromosome 11p15.4. The encoded protein is mainly mapped to the plasma membrane as well as intracellular fibrillar structures in lymphatic endothelial cells (LECs), including primary human dermal LECs and SVEC4-10 cells. LYVE1 belongs to the link module superfamily of C-type lectins.
면역원
Peptide sequence around aa. 271-275 (K-N-Q-Q-K), according to the protein LYVE1.
생화학적/생리학적 작용
LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1) plays an important role in hyaluronan homeostasis. It controls cellular trafficking of the lymph nodes. It serves as an important lymphatic vessel marker.
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1) induces activation of its ligand, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF)-A and hyaluronic acid, opens lymphatic intercellular junctions in vitro and in vivo by enhancing contraction of lymphatic endothelial cells (LECs). The encoded protein also facilitates uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
표적 설명
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
물리적 형태
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer
Bono P, et al.
Clinical Cancer Research, 10(21), 7144-7149 (2004)
Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium
Banerji S, et al.
The Journal of Biological Chemistry, 291(48), 25004-25018 (2016)
LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
Banerji S, et al.
The Journal of Cell Biology, 144(4), 789-801 (1999)
Identification of a three-gene expression signature of poor-prognosis breast carcinoma
Bieche I, et al.
Molecular Cancer, 3(1), 37-37 (2004)
Romain Parent et al.
Biochemical and biophysical research communications, 450(1), 7-12 (2014-05-24)
The endothelium lines blood and lymph vessels and protects underlying tissues against external agents such as viruses, bacteria and parasites. Yet, microbes and particularly viruses have developed sophisticated ways to bypass the endothelium in order to gain access to inner
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