SAB4300137
Anti-phospho-PRKDC (pThr2609) antibody produced in rabbit
affinity isolated antibody
동의어(들):
Anti-DNA-PKcs antibody produced in rabbit, Anti-DNAPK antibody produced in rabbit, Anti-DNPK1 antibody produced in rabbit, Anti-HYRC antibody produced in rabbit, Anti-protein kinase, DNA-activated, catalytic polypeptide antibody produced in rabbit
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모든 사진(1)
About This Item
추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
~450 kDa
종 반응성
human
농도
1 mg/mL
기술
western blot: 1:500-1:1000
동형
IgG
면역원 서열
(V-E-TP-Q-A)
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pThr2609)
유전자 정보
human ... PRKDC(5591)
면역원
Peptide sequence around phosphorylation site of threonine 2609 (V-E-T(p)-Q-A), according to the protein PRKDC.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
표적 설명
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.
물리적 형태
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Masaaki Yanai et al.
Yonago acta medica, 60(1), 9-15 (2017-03-24)
DNA double-strand breaks (DSBs) are the most cytotoxic form of DNA damage and are induced by ionizing radiation and specific chemotherapeutic agents, such as topoisomerase inhibitors. Cancer cells acquire resistance to such therapies by repairing DNA DSBs. A major pathway
Hao Zhou et al.
Basic research in cardiology, 115(2), 11-11 (2020-01-11)
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel inducer to promote mitochondrial apoptosis and suppress tumor growth in a variety of cells although its role in cardiovascular diseases remains obscure. This study was designed to examine the role of
Cindy R Timme et al.
Molecular cancer therapeutics, 17(6), 1207-1216 (2018-03-20)
Radiotherapy is a primary treatment modality for glioblastomas (GBM). Because DNA-PKcs is a critical factor in the repair of radiation-induced double strand breaks (DSB), this study evaluated the potential of VX-984, a new DNA-PKcs inhibitor, to enhance the radiosensitivity of
Tianpeng Zhang et al.
EMBO reports, 18(8), 1412-1428 (2017-06-16)
Repetitive DNA is prone to replication fork stalling, which can lead to genome instability. Here, we find that replication fork stalling at telomeres leads to the formation of
Huanrong Ma et al.
International journal of cancer, 142(12), 2578-2588 (2018-01-25)
Cetuximab resistance is a key barrier in treating metastatic colorectal cancer (mCRC). Targeting of metabolic resources import could resensitize drug-resistant cancer cells to anticancer treatments. Here we showed that the expression of the glutamine transporter solute carrier 1 family member
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