SAB4300090

Anti-phospho-MAPT (pSer²⁶²) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-DDPAC antibody produced in rabbit, Anti-FLJ31424 antibody produced in rabbit, Anti-FTDP-17 antibody produced in rabbit, Anti-MAPTL antibody produced in rabbit, Anti-microtubule-associated protein tau antibody produced in rabbit
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: ~48 kDa; ~62 kDa; ~78 kDa
• 종 반응성: rat, human, mouse
• 농도: 1 mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• 동형: IgG
• 면역원 서열: (I-G-SP-T-E)
• NCBI 수납 번호: NP_001116538.1
• UniProt 수납 번호: P10636
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pSer262)
• 유전자 정보: human ... MAPT(4137)

설명

일반 설명

MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3 It is highly expressed in neurons but is most prominent in axons

면역원

Peptide sequence around phosphorylation site of serine 262 (I-G-S(p)-T-E), according to the protein MAPT.

생화학적/생리학적 작용

Removal of MAPT (microtubule associated protein tau) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

표적 설명

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

물리적 형태

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable